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NIH Research Update - i on NIH -- episode #0023, segment 3
NIH Research Update - i on NIH -- episode #0023, segment 3
Harrison Wein, Ph.D., discusses three stories related to sleep and circadian rhythm. One is about a gene that regulates sleep length, the second is about sleep and Alzheimer's disease, and [...]
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The Molecular Basis of Alzheimer's Disease - Prof. Patrick C. Fraering
The Molecular Basis of Alzheimer's Disease - Prof. Patrick C. Fraering
This movie describes the development of Alzheimer's disease at a molecular level. It shows the very important role of the amyloid-beta peptides in the generation of deadly plaques in the brain. [...]
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Alzheimer Disease Vaccine: Closing
Alzheimer Disease Vaccine: Closing
disease is believed to be the deposition of amyloid fibrils in the brain, which ultimately leads to neurodegeneration and cognitive dysfunction. Based on the amyloid hypothesis of Alzheimers disease, many therapies presently target the amyloid beta (Aβ) peptide, [...]
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Alzheimer Disease Vaccine: Questions & Answers
Alzheimer Disease Vaccine: Questions & Answers
disease is believed to be the deposition of amyloid fibrils in the brain, which ultimately leads to neurodegeneration and cognitive dysfunction. Based on the amyloid hypothesis of Alzheimers disease, many therapies presently target the amyloid beta [...]
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Alzheimer Disease Vaccine: Introduction
Alzheimer Disease Vaccine: Introduction
disease is believed to be the deposition of amyloid fibrils in the brain, which ultimately leads to neurodegeneration and cognitive dysfunction. Based on the amyloid hypothesis of Alzheimers disease, many therapies presently target the amyloid beta (Aβ) peptide, [...]
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Apoptosis: Caspase 3 inhibitors, PMAP
Apoptosis: Caspase 3 inhibitors, PMAP
, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7, and 9; and the protein itself is processed by caspases 8, 9, and 10. It is the predominant [...]
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Insidermedicine in 60 - July 17, 2008
Insidermedicine in 60 - July 17, 2008
- Insidermedicine) From Southampton - According to research in the Lancet, immunization with a protein found in the plaques of patients with Alzheimer's doesn't prevent dementia. A significant feature of Alzheimer's is the accumulation of [...]
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Alzheimer's Disease
Alzheimer's Disease
a year, including the personality changes that can range from having no personality to being hostile. We don't know what causes Alzheimer's Disease and we don't have a cure, though medicines help delay the progressive symptoms. Only on autopsy are [...]
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Alzheimers Research Updates
Alzheimers Research Updates
Madrid's Complutense University and the Cajal Institute in Spain reported that the intracerebroventricular administration of the synthetic cannabinoid WIN 55212-2 prevented cognitive impairment and decreased neurotoxicity in rats injected with amyloid-beta peptide (a protein believed to induce Alzheimer's). Additional [...]
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Dreadful Crystals of Prion and Alzheimer Diseases
Dreadful Crystals of Prion and Alzheimer Diseases
This movie shows the crystal structures of fibril-forming segments of yeast prion protein Sup35 and Alzheimer's amyloid-beta protein(2OMM.pdb and 2ONV.pdb). The structure is termed cross-beta spines made of a pair of beta-sheets forming steric zipper [...]
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